O’Neil, et al. A tetraoxane-based antimalarial drug candidate that overcomes PfKelch 13-dependent artemisinin resistance. Accepted for Publication, Nature Communications
Aljayyoussi, G., et al. “Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration.” In press, Scientific Reports
Aljayyoussi, G. et al. “Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.” Scientific reports 7, 210, doi:10.1038/s41598-017-00322-5 (2017).
Torok, M.E, Aljayyoussi, G. (Corresponding Author) “Suboptimal Exposure to Anti-TB Drugs in a TBM/HIV+ Population is not Related to Anti-retroviral Therapy.” Clinical pharmacology and therapeutics, doi:10.1002/cpt.646 (2017).
Aljayyoussi, G., et al. “OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens.” Malaria journal 15, 344, doi:10.1186/s12936-016-1401-8 (2016).
Lestner, M., Groll, H., Aljayyoussi G. et al. “Population Pharmacokinetics of Liposomal Amphotericin B in Immunocompromised Children.” Antimicrobial agents and chemotherapy 60, 7340-7346, doi:10.1128/AAC.01427-16 (2016).
Sharma, R., Aljayyoussi G., et al. Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis. Scientific reports 6, 23458, doi:10.1038/srep23458 (2016).
Hong, W. D. et al. Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis. Journal of medicinal chemistry, doi:10.1021/acs.jmedchem.6b01718 (2017).
Al-Jayyoussi, G, et al. "Absorption of ipratropium and l-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transporters." International journal of pharmaceutics 496.2 (2015): 834-841.
Williams, N, Aljayyoussi, G. et al. "An ex vivo investigation into the transurothelial permeability and bladder wall distribution of the nonsteroidal anti-inflammatory ketorolac." Molecular pharmaceutics 11.3 (2014): 673-682.
Al‐Jayyoussi, G, et al. "Selectivity in the impact of P‐glycoprotein upon pulmonary absorption of airway‐dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout." Journal of pharmaceutical sciences 102.9 (2013): 3382-3394
Aljayyoussi, G. and Gumbleton, M., “A novel cost-effective approach for the efficient radiolabeling of dendritic macromolecules with a β-emitting radiotracer.” Tetrahedron Letters 54.9 (2013): 1045-1048.
Matthews, Ian P., Aljayyoussi, G. et al. "Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat." Environmental toxicology and pharmacology 35.3 (2013): 461-464.
Campbell, L, Aljayyoussi, G. et al. "Caveolin-1 in renal cell carcinoma promotes tumour cell invasion, and in co-operation with pERK predicts metastases in patients with clinically confined disease." Journal of translational medicine 11 (2013): 255.
Smith, MW, Al-Jayyoussi, G. and Gumbleton, M. "Peptide sequences mediating tropism to intact blood–brain barrier: An in vivo biodistribution study using phage display." Peptides 38.1 (2012): 172-180.
Gumbleton, M, Aljayyoussi G., et al. "Spatial expression and functionality of drug transporters in the intact lung: objectives for further research." Advanced drug delivery reviews 63.1 (2011): 110-118.
